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. 2007 Oct 29;204(11):2679–2692. doi: 10.1084/jem.20071068

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Reduced capacity for cytokine production by infant T cells. (A) Representative flow cytograms showing the distribution of CCR7 and CD45RA on unstimulated CD3⁺ cells from infant (left) and adult (right) macaques. All data in A–D were produced using cells from uninfected animals. (B) The graph indicates the percentage of CD4⁺ or CD8⁺ T cells that expressed CD69 after stimulation with medium or SEB. Whole blood was stimulated for 6 h, then stained with surface antibodies before lysis and data collection. Horizontal bars represent means. (C) IFN-γ production among CD3⁺ cells from infants (black symbols) and adults (gray symbols) after treatment with PMA/ionomycin for 6 h. Data for cytokine-producing naive (CD45RA⁺CCR7⁺) and memory (CD45RA⁻CCR7⁺) cells are shown. The data were produced by first gating on naive and memory cell populations and then assessing cytokine production within each subset. (D) IL-2 production among CD3⁺ cells from infants and adults. Horizontal bars in C and D represent medians.