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Predicted amino acid sequence of NaN. DI–DIV represent the four domains of Na channels, with the putative transmembrane segments underlined. The serine residue of DI-SS2 predicted to underlie the TTX-R phenotype (S355), the PKC phosphorylation site in L3 (T1321), and the tripeptide IFM in L3 involved in fast inactivation (40) are in bold and larger type, and are underlined.
