Table I.
HLA-B2705–KK10-specific TCR α and β chain repertoire
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KK10 WT in autologous virus
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KK10 L6M in autologous virus
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| Study patient | Time | TCR α chain | TCR β chain | Timea | TCR α chain | TCR β chain |
| 1 | Day 41 PP | n. d. | Vβ27-CASSQRTGELF-J2.2 (8/11) | Day 760 PP | n. d. | Vβ27-CASRVAEVNYEQY-J2.7 (4/15) |
| Vβ20.1-CSAWTSGGRADTQY-J2.3 (3/11) | Vβ5.6-CASSYSGSNYEQY-J2.7 (11/15) | |||||
| 2 | Day 0 PP | Vα19-CALGEANTGFQKLV-J8 (2/24) | Vβ5.4-CASSSTAPDTEAF-J1.1-(1/46) | Day 325 PP | Vα4-CLVVRMDSSYKLI-J12 (4/23) | Vβ6.6-CASSYSRGAGNTIY-J1.3 (1/43) |
| Vα19-CAPSEANTGFQKLV-J8 (1/24) | Vβ5.4-CASSGTAPAAEAF-J1.1 (1/46) | Vα4-CLVVWMDSSYKLI-J12 (1/23) | Vβ28-CASSLKDEQF-J2.1-(1/43) | |||
| Vα19-CALSEADTGFQKLV-J8 (1/24) | Vβ5.4-CASSLTAPDTEAF-J1.1 (32/46) | Vα1.1-CAVQSDYKLS-J20 (6/23) | Vβ24-CATGLPEGSQETQY-J2.5 (1/43) | |||
| Vα19-CALSEANTGFQKLV-J8 (LGTG) (1/24) | Vβ27-CASSRSTGELF-J2.2 (10/46) | Vα5-CAERGLMDTGRRALT-J5 (12/23) | Vβ19-CASSRRALRGYT-J1.2 (5/43) | |||
| Vα19-CALSEANTGFQKLV-J8 (FETG) (1/24) | Vβ20.1-CSARDQRDYQETQY-J2.5 (2/46) | Vβ7.2-CASSLGRGNEQF-J2.1-(2/43) | ||||
| Vα19-CALSEANTGFQKLV-J8 (18/24) | Vβ27-CASSQRTGELF-J2.2 (8/43) | |||||
| Vβ27-CASSPRTGELF J2.2 (5/43) | ||||||
| Vb20.1-CSARETSGAYNEQF J2.1(18/43) | ||||||
| 3 | Day 21 PP | Vα8.4-CAVTLLGTGGFKTI-J9 (9/18) | Vβ7.9-CANSLDGDQPGH-J1.5 (1/24) | Day 235 PP | Vα8.6-CAVSDPGFKTI-J9 (11/21) | Vβ20.1-CSAREGVEGYT-J1.2 (21/21) |
| Vα12.2-CAV NKVEFNAGGTSGKLT-J52 (9/18) | Vβ7.9-CASSLDGDQPQH-J1.5 (4/24) | Vα19-CALTDQQRAGNMLT-J39 (9/21) | ||||
| Vβ7.9-CASSLDRDEQF-J2.1 (1/24) | Vα19-CAQTDQQRAGNMLT-J39 (1/21) | |||||
| Vβ27-CASSKNQWEQY-J2.7 (7/24) | ||||||
| Vβ27-CASSPTSYEQY-J2.7 (1/24) | ||||||
| Vβ9-CASSSFDRANEQF-J2.1 (5/24) | ||||||
| Vβ20.1-CSAREGVEGYT-J1.2 (1/24) | ||||||
| Vβ20.1-CSARPGLAGELYEQY-J2.7 (2/24) | ||||||
| Vβ20.1-CSARAGLAGALYEQY-J2.7 (2/24) | ||||||
PP, days after presentation off therapy.
a
Time points were chosen based on sample availability and might not necessarily reflect the time when the L6M mutation first emerged.