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. 2007 Nov 26;204(12):2789–2796. doi: 10.1084/jem.20070607

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — Effective uptake and universality of the M cell–targeted mucosal vaccine. (A) Immunocytochemical analysis showed that an M cell–targeted OVA vaccine composed of Alexa Fluor 647–conjugated OVA, FITC-conjugated avidin, and NKM 16–2-4 specifically reacted with isolated UEA-1–positive M cells. (B) In an intestinal loop assay, the M cell-targeted OVA specifically attached to the apical surfaces of M cells (red arrows) and was immediately taken up into the cytoplasmic regions of M cells. Bars, 10 μm. (C) Orally administered OVA-conjugated NKM 16–2-4 effectively induced an OVA-specific serum IgG response, whereas an OVA-conjugated control rat IgG did not. Data are expressed as the mean ± the SD.