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. 2007 Nov 26;204(12):3037–3047. doi: 10.1084/jem.20070885

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — The ischemic myocardium sequentially recruits circulating Ly-6C^hi and -6C^lo monocytes. (A) Number of total leukocytes in peripheral blood of C57BL/6 mice before MI and at the onset of phase I (day 1 after MI) and phase II (day 4). (B) Number of circulating Ly-6C^hi and -6C^lo monocytes at the same time points. Values in the top right quadrants indicate the ratio between the two subsets. (C) In vivo cardiac accumulation of ¹¹¹In-oxine-labeled Ly-6C^hi and -6C^lo monocytes 24 h after adoptive transfer on day 0 (phase I) and day 4 (phase II). Values in the top right quadrants indicate the ratio between the two subsets. (D) Adoptively transferred ¹¹¹In-oxine–labeled Ly-6C^hi monocytes compete with endogenous Ly-6C^hi monocytes. Increased numbers of endogenous circulating Ly-6C^hi monocytes (x axis) decrease the ratio between transferred and endogenous Ly-6C^hi monocytes (label frequency, y axis) that migrated into the peritoneal cavity of mice with peritonitis (Table S1). (E) Pie graph representing the relative proportion of Ly-6C^hi and -6C^lo monocyte subsets expected to accumulate in infarct tissue, based on the mean abundance of each subset in peripheral blood (B) and the intrinsic capacity of circulating cells from each subset to accumulate at infarct tissue (C). Data represent three independent experiments and are shown as the mean ± the SEM. Table S1 is available at http://www.jem.org/cgi/content/full/jem.20070885/DC1.