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. 2007 Nov 26;204(12):3017–3026. doi: 10.1084/jem.20071289

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Splenic B cells from ape1^+/−, ape2^Y/−, and DBL mice proliferate normally upon CSR induction. Splenic B cells were stained with CFSE and cultured for 3 d with LPS plus IL-4 and analyzed by FACS. (A) Overlay CFSE histograms of ex vivo B cells immediately after CFSE staining and after 3 d of stimulation are shown. CFSE fluorescence is represented by red profiles for WT splenic B cells, and by blue profiles for ape1^+/−, ape2^Y/−, and DBL splenic B cells. (B) Computational integration of the level of CFSE fluorescence in B cells stimulated for IgG1 switching. The numbers of cell divisions are given above the CFSE peaks.