Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2007 Nov 26;204(12):2899–2912. doi: 10.1084/jem.20071030

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2007, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 6. — Analysis of total and EBV-specific OCBs in postmortem CSF from MS cases. The graphs show (A) significantly higher numbers of OCBs in the CSF of EBV-high MS cases (n = 7) versus EBV-low MS cases (n = 9) and (B) no difference in the number of EBV-specific OCBs between EBV-high and EBV-low MS cases. Dot points represent values for each MS case, and the bars represent median values for each group. p-values, calculated by the Mann-Whitney U test, are indicated where statistically significant. (C) Affinity-mediated immunoblotting on EBV antigen-coated nitrocellulose paper of isoelectrofocused CSF from two EBV-low MS cases (lanes 1 and 2 correspond to MS154 and MS102 in Table S1, respectively), anti-EBV EA-D monoclonal (mo) antibody used as positive control (lane 3), and serum (ser) from a patient with monoclonal IgG used as control for binding specificity (lane 4). An additional control for binding specificity included CSF from the MS102 case that was blotted onto casein-coated nitrocellulose paper (absence of reactivity; lane 5). Faint (lane 1) and both faint and strong (lane 2) EBV-specific OCBs are present in MS154 and MS102 cases, respectively (arrows indicate OCBs). Of note, MS102 was also positive for EBV DNA and had the highest frequency of EBER⁺ and CD8⁺ cells in white matter lesions and meninges among the EBV-low MS cases.