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. 2007 May 14;204(5):1145–1156. doi: 10.1084/jem.20061952

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Phylogenetic analysis of Aicda. AID locus in human chromosome 12. Homology “peaks and valleys” graph showing percent conservation between human, dog, and mouse AID genomic loci. The nucleotide sequence is plotted on the horizontal axis. The vertical axis depicts the percent identity between the three species. Only conserved regions containing at least one peak with percent identity >75% within a shifting window of 100 bp in all three species are represented. Red peaks correspond to gene exons, whereas black peaks denote CNSs (I–XI). Genes and their orientation are represented by their RefSeq name and by arrows, respectively. As in the human, the mouse and dog Mfap5 and Kiaa1238 orthologs are located 5′ of Aicda and form a synteny group within the 1 MB interval analyzed. Conversely, the mouse and dog Clecsf9 and Clecsf8 genes are located beyond the 1 MB sequence analyzed here, and no homology is therefore assigned to these genes. Alignment was obtained using Family Relations (http://family.caltech.edu/) and VISTA software (http://www-gsd.lbl.gov/vista/index.shtml).