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. 2007 May 14;204(5):1145–1156. doi: 10.1084/jem.20061952

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — H3 acetylation status at the AID locus. (A) Percent homology identity between the dog, human, and mouse genomes as a function of the mouse AID locus in chromosome 6. Homology peaks and genes are depicted as in Fig. 1. Black dots represent the position of quantitative PCR primers used to assess H3 acetylation by CHIP. AID exons are marked with yellow boxes. E, EcoRV; S, SalI; X, XbaI. (B) Absolute percentage of histone H3 acetylation from resting (blue circles) or LPS-activated (red squares) B cells. (C) DNaseI hypersensitivity at CNS VII and X. Nuclei prepared from LPS-activated mouse B cells were untreated (lane 1) or treated with increased concentrations of DNaseI (lanes 2–6). DNA was extracted, digested, and analyzed by Southern blot hybridization using VII- or X-specific probes (PVII and PX, respectively). Horizontal arrows indicate DNaseI hypersensitive sites that correlate with CNS-X. (D) Detailed map of mouse CNS X. Elements A and B (red boxes) depict two highly conserved sequences between mouse and humans that correlate with the Southern blot bands obtained by DNaseI hypersensitivity. Putative transcription factor binding sites in elements A and B, predicted using VISTA software, are shown.