Figure 5.

CD4⁺ T cells promote development of breast cancer tumors through DCs. (A) Experimental scheme. (B) 100 μl PBS or 10 × 10⁶ CD4⁺ and CD8⁺ T cells/100 μl PBS were transferred into Hs578T tumor-bearing mice. The tumor size 12 d after tumor inoculation is shown for two experiments (nine mice per group). Horizontal bars represent the mean. (C) 100 μl PBS, and 10⁶ DCs/100 μl PBS and 10 × 10⁶ autologous CD4⁺ T cells/100 μl PBS, or both, were transferred into Hs578T tumor-bearing mice. Tumor growth was monitored (three mice per group; mean ± SD).