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. 2007 May 14;204(5):1227–1235. doi: 10.1084/jem.20070145

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — LIMP-2 expression is up-regulated in other forms of mechanical loading. In neonatal rat cardiac myocytes, 6 h of stretch elevated LIMP-2 mRNA expression (n = 4 per group) (a). LIMP-2 expression was also up-regulated in hypertrophic myocardium from rats that had undergone exercise training for 10 wk (5 d per week; n = 6) as compared with nonhypertrophic control rats (n = 7) (b). After 1 h of transverse aortic banding in mice, LIMP-2 protein is elevated (c). LIMP-2 mRNA is up-regulated in hypertrophic patients with aortic stenosis (LVH; n = 20) as compared with nonhypertrophic control patients (n = 7) (d). *, P < 0.05 versus control; **, P < 0.01 versus control; LVH; LV hypertrophy.