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. 2007 May 14;204(5):1083–1093. doi: 10.1084/jem.20061273

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — SEMA 7A, PI3K, PKB/AKT, and myofibroblast accumulation. Tg⁻ and Tg⁺ mice with WT and null SEMA 7A loci were generated and evaluated after 2 wk of Tg activation. The levels of phosphorylation of PI3K and PKB/AKT were evaluated using Western blots with antibodies against the two forms of pAKT and PI3K (A). Myofibroblast accumulation was assessed using IHC (B) and Western evaluations (C) with antibodies against α-smooth muscle actin (solid arrows) and myosin (open arrows). Sircol assays were used to evaluate the effects of PKB/AKT inhibition (Akt-In) on collagen accumulation after 10 d of Dox incubation (D). A–C are representative of five similar evaluations. The values in D represent the mean ± SEM of evaluations in a minimum of five mice. *, P < 0.01.