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. 2007 May 14;204(5):1025–1036. doi: 10.1084/jem.20061825

Figure 2.

Figure 2.

Resistance of IRAK4 kinase–inactive knock-in mice to LPS and CpG ODN-induced septic shock. (a) Age-matched wild-type (WT) and IRAK4 kinase–inactive knock-in (KI) mice (10 mice per group) were injected intraperitoneally with LPS (40 mg/kg body weight). Survival was monitored for 10 d. (b) Age-matched WT and KI mice (10 mice per group) were injected intraperitoneally with CpG ODN (0.8 mg/kg body weight) and d-GalN (20 mg). Survival was monitored for 10 d. (c) Serum concentration of TNF-α and IL-6 from WT and KI mice at 2 h after LPS injection was measured by ELISA. Results shown are the mean (± SD) of triplicate determinations. (d) Serum concentration of TNF-α and IL-6 from WT and KI mice at 2 h after CpG ODN injection was measured by ELISA. Results shown are the mean (± SD) of triplicate determinations. (e) Serum concentration of TNF-α and IL-6 from WT and KI mice at 2 h after IL-1β (40 μg/kg body weight) injection was measured by ELISA. Results shown are the mean (± SD) of triplicate determinations.