Table 1.
Percentage of control responses as shown in Fig. 1 (measured before and after mGluR ligand coapplication), mean ± SEM
| [Agonist] | 10 μM Glycine (saturating)
|
1.5 μM glycine (EC50)
|
||||||
|---|---|---|---|---|---|---|---|---|
| 10 μM NMDA
|
50 μM NMDA (EC50)
|
500 μM NMDA (saturating)
|
50 μm NMDA (EC50)
|
|||||
| MGluR ligand | Mean ± SEM | n | Mean ± SEM | n | Mean ± SEM | n | Mean ± SEM | n |
| MCPG | 104 ± 3 | 3 | 86 ± 1 | 4 | 100 ± 4 | 7 | 71 ± 2 | 6 |
| DHPG | 108 ± 5 | 3 | 71 ± 7 | 5 | 97 ± 3 | 7 | 46 ± 8 | 3 |
| 3-HPG | 102 ± 12 | 3 | 74 ± 8 | 4 | 100 ± 6 | 7 | 218 ± 20 | 7 |
| 1S,3R-ACPD | 147 ± 10 | 3 | 86 ± 3 | 6 | 98 ± 6 | 7 | 7 ± 4 | 7 |
| trans-ADA | 134 ± 12 | 5 | 96 ± 1 | 4 | 106 ± 5 | 7 | 80 ± 1 | 4 |
| DL-AP4 | 105 ± 12 | 7 | 104 ± 10 | 5 | 115 ± 18 | 7 | 224 ± 38 | 7 |
| AIDA | 74 ± 5 | 4 | 85 ± 4 | 7 | 106 ± 5 | 4 | 79 ± 3 | 4 |
Data are for n determinations. Responses that were significantly different from control (P < 0.05), are indicated in boldface with P values as given in Fig. 1.