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. 2007 Jun 11;204(6):1383–1393. doi: 10.1084/jem.20061205

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Inflammatory cells and cytokines present in BALF 48 h after infection with K. pneumoniae. (A) Total number of cells present in the airways and thus recovered by BAL was higher in the lungs of NKCC1^−/− mice (n = 30) than NKCC1^+/+ mice (n = 29). (B) Cells present in the BAL were stained and identified based on morphological criteria. There was a statistically significant difference in the number of neutrophils in NKCC1^−/− mice compared with wild-type controls. Macrophages remained unchanged in both groups. TNF-α, IL-1β, IL-10, and IL-6 levels were determined in the lung homogenates by ELISA kits. NKCC1^−/− mice exhibited increased levels of (C) TNF-α and (D) IL-1β, but the increased levels did not reach statistical significance compared with littermate controls. (E) IL-10 levels were significantly reduced in NKCC1^−/− mice compared with NKCC1^+/+ mice. (F) IL-6 levels were also reduced in NKCC1^−/− mice in comparison to NKCC1^+/+ mice, but the reduced levels were not significant. Data are expressed as mean ± SEM; n = 7–10 mice per group for cytokine assays. *, P < 0.05; **, P < 0.005. conc., concentration.