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. 2007 Jun 11;204(6):1383–1393. doi: 10.1084/jem.20061205

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — Assessment of bacterial load, cellular infiltrates, and edema formation after induction of peritonitis with K. pneumoniae in NKCC1^−/− and wild-type mice. (A) CFUs in the peritoneal lavage fluid of NKCC1^+/+ and NKCC1^−/− mice. Bacterial load was slightly lower in NKCC1^−/− mice, but the reduced levels did not reach statistical significance (7–8 mice per group). (B) The total number of cells collected by peritoneal lavage was significantly decreased in NKCC1^−/− mice compared with littermate controls (P = 0.04). (C) Differential cell counts were determined, based on morphological criteria, of cells present in the peritoneal lavage fluid of infected mice. A significant decrease was observed in the number of peritoneal macrophages in NKCC1-deficient mice compared with wild-type controls (P = 0.016). Emigrated neutrophils were present 1 h after K. pneumoniae infection. However, NKCC1-deficient mice showed no compromise in neutrophil emigration compared with NKCC^+/+ mice. (D) Consistent with a less robust inflammatory response, edema formation was significantly reduced in NKCC1^−/− mice compared with littermate controls. Values are shown as mean ± SEM; n = 15–18 mice per group. *, P < 0.05.