Figure 6.

Viral titers in organs of BM chimeric mice after reovirus T1L infection. C57BL/6 mice (open black squares), IFNαR1 KO mice (open red triangles), IFNαR1 KO mice reconstituted with C57BL/6 BM cells (open green circles), and C57BL/6 mice reconstituted with IFNαR1 KO BM cells (open blue diamonds) were inoculated perorally with T1L and killed at the indicated times. Viral titers in homogenates of the organs shown were determined by plaque assay. Each data point represents viral titer in a tissue sample from a single mouse. Horizontal bars indicate mean viral titers. *, P < 0.05; **, P < 0.001, as determined using a one-tailed Student's t test.