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. 2007 Jun 11;204(6):1417–1429. doi: 10.1084/jem.20061929

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — C3GnT^−/− mice have more severe DSS-induced colitis. (A) Survival rate of a cohort of 10 age-matched C3GnT ^+/+ and C3GnT ^−/− males after a 14-d, 2.5% DSS treatment. (B–D) Percent body weight changes compared with baseline, diarrhea score, and fecal blood score in 6-wk-old C3GnT ^+/+ and C3GnT ^−/− males after a 7-d, 2% DSS treatment. Each point represents the mean ± the SEM. n = 10. (E) Hematoxylin and eosin–stained colonic tissues of C3GnT ^+/+ and C3GnT ^−/− mice with or without 2% DSS treatment. Bar, 100 μm. (F) Histopathological scores of C3GnT ^+/+ and C3GnT ^−/− mice 7 d after 2% DSS treatment based on degrees of inflammatory cell infiltration and epithelial injury. Error bars indicate mean ± the SEM. n = 12.