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. 2007 Jul 9;204(7):1533–1541. doi: 10.1084/jem.20062120

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Expression of CD25, CD45RO, IL-7Rα, and FOXP3 on blood CD4 T cells of stable transplant recipients and kidney transplant recipients with chronic rejection. Blood mononuclear cells from 32 stable transplant recipients (11 kidney and 21 liver transplant recipients) and 4 kidney transplant recipients with biopsy-proven chronic rejection were analyzed for the surface expression of CD4, CD25, CD45RO, and IL-7Rα and for the intracellular expression of FOXP3. (A) Means ± SE of cumulative data on the proportion of CD4⁺CD25⁺ T cells in stable transplant recipients and transplant recipients with chronic rejection. The percentage of CD4⁺CD25⁺ T cells in total CD4⁺ T cells was slightly increased in transplant recipients with chronic rejection compared with stable transplant recipients, but these differences were not significant (P = 0.21). (B) Means ± SE of cumulative data on the proportion of CD4⁺CD25⁺FOXP3⁺IL-7Rα^low T cells in stable transplant recipients and transplant recipients with chronic rejection. The proportion of FOXP3⁺IL-7Rα^low T cells within the CD4⁺CD25⁺ T cell population was slightly reduced in the patients with chronic rejection compared with stable transplant recipients, and these differences were significant (P = 0.01).(C) Means ± SE of cumulative data on the proportion of CD4⁺CD25⁺CD45RO⁺IL-7Rα^high T cells in stable transplant recipients and transplant recipients with chronic rejection. The proportion of CD45RO⁺IL-7Rα^high T cells within the CD4⁺CD25⁺ T cell population was significantly increased in the chronic rejection group compared with the stable group (P < 0.0001).