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. 2007 Jul 9;204(7):1653–1664. doi: 10.1084/jem.20062648

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Decreased splenic DC content after RBP-J deletion in the BM. Control (RBP-J^fl/fl) or CKO (RBP-J^fl/fl Mx1-Cre⁺) mice were injected with poly(I):(C) to induce the deletion of RBP-J in the BM. 3 wk later, spleens were analyzed by flow cytometry, and BM was transferred to irradiated recipients. (A) Splenic DC compartment in control and CKO mice. Shown are the staining profiles of total splenocytes (or of B220⁺ splenocytes for PDCs), with the fraction of each population in the total splenocytes indicated (mean ± SD of three animals). (B) Splenic DC compartment in the chimeras established from control or CKO BM. Shown are the staining profiles of donor-derived (CD45.2⁺) splenocytes 4–5 wk after BM transfer, with the fraction of each population in the total donor-derived splenocytes indicated (mean ± SD of four to six animals). Student's test p-values are indicated for statistically significant differences.