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. 2007 Jul 9;204(7):1553–1558. doi: 10.1084/jem.20070823

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — Dicer deficiency in Purkinje cells causes ataxia. (A) Rotarod test on Pcp2-Cre; Dicer^flox/flox mice compared with their littermate controls. Statistical analysis was performed using Anova single factor analysis (F = 5.976822099; P = 0.00024395; F crit = 2.41735603). Latency to fall from the rod was measured in control Pcp2-Cre; Dicer^+/flox (gray) and mutant Pcp2-Cre; Dicer^flox/flox (black) mice at 8 (control, n = 10; mutant, n = 8; P = 0.73494913), 13 (control, n = 10; mutant, n = 7; P = 0.28503378), and 17 (control, n = 9; mutant, n = 8; P = 0.00016573) wk of age. Results are expressed as means, and error bars represent ± SEM. p-values are from the unpaired two-tailed Student's t test. (B) Footprint analysis. Footprints of 17-wk-old male control and Pcp2-Cre; Dicer^flox/flox mice are shown. The mutant animal exhibits a wide-based ataxic gait. Red, front paws; black, hind paws.