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. 2007 Aug 6;204(8):1875–1889. doi: 10.1084/jem.20061134

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Ligation of Fcγ receptors modulates TLR-4–mediated cytokine production from DCs. (A) BMDCs generated from BALB/c (filled bars) or C.C3-Tlr4^Lps-d (TLR-4^−/−) (open bars) mice were loaded with immune complexes produced by incubation of OVA with anti-OVA sera (OVA-IC) or OVA mixed with an aliquot of antisera in which IgG had been depleted (OVA-IgG^depl) to account for potential nonspecific effects from the antisera (***, P < 0.001; n.d., not detected). (B) BALB/c (filled bars) or TLR-4^−/− (open bars) BMDCs were cultured on plates coated with the indicated concentration of anti-FcγRIIb/RIII (2.4G2) in the presence of 10 ng/ml LPS. After 24 h of culture, cytokine production from the BMDCs was estimated. Fcγ receptor–mediated modulation of cytokine production was significantly reduced in the TLR-4^−/− BMDCs as compared with BALB/c BMDCs (P < 0.005 by two-way ANOVA analysis). The data shown in A are representative of three independent experiments, and those presented in B are representative of two independent experiments.