Table I.

FBW7 is mutated in a high percentage of primary human T-ALL samples

Patient number	Diagnostic/relapse sample	FBXW7 sequence NM_033632.2	Predicted amino acid change
602-783	Diagnosis	C1542T	R465C
603-932	Diagnosis	C1542T	R465C
1	Diagnosis	NA	NA
	Relapse	C1542T (homozygous)	R465C
4	Diagnosis	WT	WT
	Relapse	C1542T	R465C
17	Diagnosis	C1542T	R465C
	Relapse	C1542T	R465C
16	Diagnosis	G1543A	R465H
	Relapse	G1543A	R465H
602-455	Diagnosis	G1543A	R465H
601-268	Diagnosis	G1543A	R465H
27	Diagnosis	WT	WT
	Relapse	G1543A	R465H
4451	Diagnosis	G1585A	R479Q
602-839	Diagnosis	G1585A	R479Q
603-473	Diagnosis	G1585A	R479Q
29	Diagnosis	C1662T	R505C
	Relapse	C1662T	R505C
22	Diagnosis	WT	WT
	Relapse	C1662T	R505C
35	Diagnosis	WT	WT
	Relapse	G1663T	R505L