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. 2007 Aug 6;204(8):1945–1957. doi: 10.1084/jem.20070133

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — Runx1 requirement in the differentiation of DN thymocytes. (A) CD4 and CD8 expression in total thymocytes (top) and CD25 and CD44 expression in CD4^lo/−CD8⁻TCRβ⁻ thymocytes (bottom) from Runx1 ^F/F;Lck-cre mice and littermate Runx1 ^F/F control mice. Percentages of cells are shown in the indicated gates. (B and C) CD25 and icTCRβ (B) and icTCRβ and TCRγδ (C) in CD4^lo/−CD8⁻TCRβ⁻ thymocytes are shown. Gates used for population definition and frequencies of the gated population in CD4^lo/−CD8⁻TCRβ⁻ thymocytes are indicated. (D) Incorporation of BrdU by the thymocyte subpopulations defined in B. Numbers indicate the percentages of BrdU⁺ cells defined by the interval gates. (E) Absolute numbers of thymocytes in immature thymocyte subpopulations from Runx1 ^F/F;Lck-cre mice (closed bars) and littermate Runx1 ^F/F mice (open bars) are shown. Data were averaged from five mice with standard deviations.