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. 2007 Aug 6;204(8):1945–1957. doi: 10.1084/jem.20070133

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Runx1 is required for positive selection and maturation of CD4SP thymocytes. (A) Expression of CD4, CD8, TCRβ, CD69, and HSA (CD24) in thymocytes from Runx1 ^F/F;Cd4-cre and littermate Runx1 ^F/F mice (top) is shown. Percentages of cells are shown in the indicated gates. (B) TCRβ expression of total thymocytes from Runx1 ^F/F;Cd4-cre (open histogram) and littermate Runx1 ^F/F (shaded histogram) mice. (C) CD4 and CD8 expression in thymocytes gated for TCRβ^hiHSA^hi (top) and TCRβ^hiHSA^lo (bottom) from Runx1 ^F/F;Cd4-cre and littermate Runx1 ^F/F mice. Percentages of CD4⁺CD8⁻ thymocytes in the gated rectangles are shown. (D) Development of CD4SP and CD8SP thymocytes in Runx1 ^F/F;Cd4-cre and littermate Runx1 ^F/F;Cd4-cre; b2m ^−/− mice. The percentages of CD4SP and CD8SP mature thymocytes are shown. (E and F) The absolute numbers of total thymocytes and DP thymocytes (E) and mature thymocyte subpopulations (F) are shown as the mean and standard deviation from 4–10 mice with the indicated genotypes. Statistical differences were tested by the Student's t test. *, P < 0.05; **, P < 0.01.