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. 2007 Aug 6;204(8):1999–2008. doi: 10.1084/jem.20070304

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Localization of vascular pathology in AD mice deficient for fibrinogen or fibrinolysis. (A–F) Composite images of cerebral hemispheres of 6-mo-old mice perfused with Evans blue for 6 h. TgCRND8;fib^+/− (D) and TgCRND8;plg^+/− (F) mice are compared with TgCRND8 mice (E) and fib^+/− (A), NTg (B), and plg^+/− (C) controls. Pathologic dye accumulation is most apparent in the cortex (cx), hippocampus (hp), and thalamus (th).