Figure 7.

Fibrin deposition and vascular damage are modified by manipulation of fibrinogen levels and fibrinolysis. (A) Representative images of perfused brains from each treatment group stained for fibrin. Images were tiled together using a motorized stage on a confocal microscope. (B) Evans blue extravasation from ancrod-, saline-, and tranexamic acid–treated 6-mo TgCRND8 mice. Data are represented as mean ± SEM of each treatment group, where n = 3 for each group. *, P < 0.05, relative to saline-treated mice. Fibrinogen depletion with ancrod reduces vascular damage, whereas plasmin inhibition enhances permeability. (C) High-magnification images of fibrin deposition (green) with Aβ plaques (red). Bar, 20 μm.