Figure 7.

Allergen-induced airway inflammation is attenuated in CIITA^Tg mice. Total BALF cells (A) and percentages of differential cell counts (B) in the BALF of WT and CIITA^Tg mice 48 h after the last OVA aerosol treatment were determined. Each symbol in the graphs represents one mouse. Eos, eosinophils; Neu, neutrophils; LM, lymphocytes; MC, monocytes. (C) Reduced perivascular eosinophilic infiltration in CIITA^Tg lung sections 2 d after the last exposure to OVA. Eosinophils are the red-staining cells in the H&E lung sections. Bars: (top) 100 μm; (bottom) 25 μm. (D) OVA-specific serum IgE levels. (E) Real-time RT-PCR of cytokine mRNA levels in the lung tissue of the OVA-challenged mice. The error bars represent the mean ± SD of six mice in each group. Horizontal lines in A and D represent median values. The Student's two-tailed t test was used to calculate statistical significance. Data are pooled from two independent experiments. P < 0.05 was considered statistically significant. *, P < 0.05; **, P < 0.01.