Table I.
Relationship of the potency of antigen presentation in BM chimeras and the Th cell phenotype
| Mice | MHC II expression
|
Ii and H-2M
|
||||
|---|---|---|---|---|---|---|
| TECs | Thymocytes | TECs | Thymocytes | Predicted potency of antigen presentation |
Th2 cytokine production by Th1 cells |
|
| B6 | + | − | + | − | TEC | N |
| CIITATg | + | + | + | + | TEC = thy | Y |
| CIITATg/CIITA−/− | − | + | − | + | thy | Y |
| I-ETg | + | + | + | − | TEC > thy | N |
| I-ETg/Aβ−/− | + | + | + | − | TEC > thy | N |
| I-ETg/CIITA−/− | + | + | − | − | TEC = thy | Y |
| CIITATg→B6 | + | + | + | + | TEC = thy | Y |
| CIITATg→Aβ−/− | − | + | + | + | thy | Y |
| CIITATg→CIITA−/− | − | + | − | + | thy | Y |
| CIITATg/Aβ−/−→B6 | + | − | + | + | TEC | N |
| I-ETg→B6 | + | + | + | − | TEC > thy | N |
| I-ETg→Aβ−/− | − | + | + | − | thy | Y |
| I-ETg/CIITA−/−→B6 | + | + | + | − | TEC > thy | N |
| I-ETg/CIITA−/−→Aβ−/− | − | + | + | − | thy | Y |
Mice indicated with → are BM chimeras. Cells expressing MHC class II, Ii, and H-2M are considered hypothetically more potent than the cells expressing MHC class II in the absence or in low levels of Ii and H-2M. Expression denoted with − includes cells that express none or a low level of the indicated molecules. = or > show an equivalent or a stronger potency of antigen presentation function, respectively. Th2 cytokine production was experimentally determined using ICS. N, no; Y, yes.