Figure 4.

Brain-infiltrating CD8 T cells were not fully activated in this model of antigen-specific CD8 T cell traffic. (A–I) Representative sections 3 d after intrastriatal injection of HA in CL4 mice immunized intradermally with CFA alone (A–C) or HA in CFA (D–F) 5 d previously, and in wild-type littermates receiving 3 million in vitro−activated CL4 CD8 T cells i.v. (G–I). Sections were submitted to immunohistochemistry (brown) for granzyme B (A, D, and G), amyloid precursor protein (B, E, and H), or Luxol Fast Blue histochemistry (C, F, and I). Bars are 60 μm except for the following: A, 30 μm; D, 20 μm; G, 10 μm.