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L. major NIH/Sd infection in C57BL/6 mice. (A) In intact animals, IFN-γ–producing Th1 cells only partially control the infection, and nonhealing lesions are established. (B) Blocking the production of IL-10 by Foxp3− Th1 cells increases the Th1 effector response, which helps clear the infection. (C) Depleting Foxp3+ T reg cells increases the parasite burden in parallel with the production of IL-10 and Th2 cytokines, resulting in increased susceptibility to infection.
