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. 2007 Feb 19;204(2):245–252. doi: 10.1084/jem.20061826

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Intrathecal injection of lipoxins reduces inflammation-evoked hyperalgesia. Paw withdrawal latency (PWL) is plotted versus time for the left ipsilateral (ip) and contralateral (c) hind paw, showing that i.t. pretreatment (−2 min) with equimolar doses of LXA₄ (A and C), LXB₄, and ATLa and a higher dose of 8,9-aLXB₄ (B and C), as well as posttreatment with LXA₄ (injection at 120 min or at 120 min followed by a second injection at 190 min; E and F), reduces inflammation-evoked hyperalgesia. HI is calculated for 0–4 h (C) and 2–6 h (F). None of the i.t.-delivered lipoxins altered paw thickness (D). Each time point and bar represents the mean ± SEM (n = 6–8). *, P < 0.05 as compared with vehicle (ip) measurements.