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. 2007 Feb 19;204(2):369–380. doi: 10.1084/jem.20061334

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — Thymic generation of nTreg cells in WAS^−/− mice. (a) Thymic development of nTreg cells in WT and WAS ^−/− mice. CD4/CD8 flow cytometric plots were gated on live thymocytes, total Foxp3⁺ cells, and mature CD24^loFoxp3⁺ cells. Numbers indicate the percentage of cells in the respective region. Data are representative of 12 mice per group analyzed in three independent experiments. (b) Immunophenotype of CD4⁺ single positive thymocytes from representative WT and WAS ^−/− mice. Numbers indicate the percentages and MFI of CD25⁺ cells. (c) Percentage, absolute count, and MFI of CD25⁺ cells among CD4⁺ single positive thymocytes. Mean ± SD of 13 mice per group are shown. (d) Foxp3 and CD25 expression in CD4⁺ single positive thymocytes. Numbers indicate the percentage of cells in the respective region. (e) Absolute count of the indicated thymocyte populations. Mean ± SD of 13 mice per group is shown. *, P < 0.05, Student's t test.