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Nucleotide and amino acid sequence of PDE8. Note the in-frame stop codon above the predicted start methionine is marked by ∗∗∗. Underlined amino acid residues correspond to a nuclear localization consensus sequence. (A) The N-terminal PAS domain is homologous to many signaling proteins (see Fig. 5). (B) The catalytic domain of PDE8. ∗ denotes the stop codon at the end of the ORF.
