Figure 1.

Inhibition of isoproterenol-stimulated renin release by 8-pCPT-cGMP in the isolated perfused rat kidney. Baseline renin release was measured between 20 and 30 min after perfusion begin. Subsequently, isoproterenol (3 nM) was added to the perfusate, and at the indicated time, 8-pCPT-cGMP (30 μM) was either added (•) or not added (○) to the perfusate. Perfusate samples withdrawn from both the arterial and venous sides of the kidney at the times indicated were used to calculate the renin secretion rate expressed as nanogram of AT I formed from angiotensinogen/h of assay conversion time/min of perfusion/g of kidney weight. Shown are the means ± SEM of results from five perfused kidneys.