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. 2006 May 15;203(5):1329–1342. doi: 10.1084/jem.20060268

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Copyright © 2006, The Rockefeller University Press

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Figure 7. — E47 and Notch signaling act in concert to induce T cell commitment at the expense of myeloid lineage development. Lin⁻ progenitors (10⁵ cells) derived from E14 E2A^+/+, E2A^+/−, and E2A^−/− fetal livers were cultured on OP9-DL1 stromal cells for 7 d with DMSO alone or in the presence of γ-secretase inhibitor IX at the indicated concentrations. (A) Flow cytometry analysis indicating the expression of Mac1 and CD19. The percentages of the number of cells present in the various compartments are indicated. (B) Total number of Mac1⁺ cells generated from 10⁵ Lin⁻ cells of E2A^+/+, E2A^+/−, and E2A^−/− fetal livers cultured for 7 d on OP9-DL1 cells at the indicated concentration of γ-secretase inhibitor.