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. 2006 May 15;203(5):1343–1355. doi: 10.1084/jem.20060028

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Selective expansion of IE-CTLs expressing activating CD94/NKG2C receptors in celiac disease. Representative flow cytometric data on freshly isolated TCR-αβ⁺CD8⁺ IE-CTLs or PB-CTLs from normal controls (Cntrl), AC patients, and celiac patients on a GFD are shown in the right panels. A scatter plot graph summarizing all samples investigated is shown on the right in A–D. (A) Decreased frequency of IE-CTLs expressing inhibitory CD94/NKG2A receptors in AC patients and GFD patients. (B) Increased frequency of IE-CTLs expressing surface CD94/NKG2C receptors in AC patients and GFD compared with controls. (C) Increased frequency of IE-CTLs expressing intracellular NKG2C protein (NKG2C IC) in AC patients and GFD compared with controls. (D) Propensity toward an increased frequency of PB-CTLs expressing surface CD94/NKG2C receptors in AC patients and GFD compared with controls. (E) CD94-dependent HLA-E recognition by CD94/NKG2C⁺ CTLs. A representative example of HLA-E staining on gated TCR-αβ⁺CD8⁺ NKG2C⁺ CTLs is shown on freshly isolated PBLs. Left panel shows that incubation with anti-CD94 antibody before incubation with a HLA-E tetramer prevents staining with the HLA-E tetramer.