Table 2.

Lactate values (mmol/L) according to the exposure to antiretroviral prophylaxis and the timing of the blood collection. ANRS 1209 study, Abidjan, Côte d’Ivoire (2002–2005).

	Overall	Control group	Exposedgroup
		Cohort 3 sdNVP	All	Cohort 1 ZDV+ sdNVP	Cohort 2 ZDV+3TC+ sdNVP	p*	p**	p***
Lactate values (total)
Number of samples	836	194	642	323	319
Min-Max	0.2–11.7	0.6–6.3	0.3–11.7	0.3–10.5	0.2–11.7
Mean (SD) mmol/L	2.2 (1.4)	2.3 (1.1)	2.2 (1.5)	2.0 (1.1)	2.3 (1.6)	0.009	0.530	0.242
Lactate values (week-4)
Age of infants (days)	29 [28–31]	31 [29–34]	28 [28–30]	29 [28–30]	28 [28–30]		0.570
Number of samples	299	73	226	117	109
Min-Max	0.2–11.7	0.9–5.7	0.2–11.7	0.6–7.5	0.2–11.7
Mean (SD) mmol/L	2.2 (1.4)	2.2 (0.9)	2.2 (1.5)	2.1 (1.1)	2.3 (1.8)	0.283	0.976	0.499
Lactate values (week-6)
Age of infants (days)	44 [42–46]	46 [44–50]	44 [42–46]	44 [42–46]	44 [42–46]
Number of samples	264	65	199	101	98
Min-Max	0.3–10.5	0.9–5.7	0.3–9.9	0.6–10.5	0.3–9.9
Mean (SD) mmol/L	2.4 (1.5)	2.3 (1.2)	2.2 (1.5)	2.2 (1.5)	2.6 (1.9)	0.149	0.638	0.273
Lactate values (month-3)
Age of infants (days)	92 [90–93]	93 [92–100]	91 [90–92]	93 [92–94]	91 [90–92]
Number of samples	264	65	170	79	91
Min-Max	0.3–8.1	0.9–6.3	0.3–8.1	0.3–6.3	0.4–8.1
Mean (SD) mmol/L	2.1 (1.1)	2.3 (1.1)	2.0 (1.2)	1.7 (1.1)	2.2 (1.1)	0.006	0.104	0.006

sdNVP = single-dose of nevirapine, ZDV = zidovudine, 3TC = lamivudine

^*Comparison between the two exposed groups,

^**Comparison between exposed (all) and control groups,

^***Comparison between the three groups

SD: Standard deviation