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. Author manuscript; available in PMC: 2007 Dec 7.
Published in final edited form as: Hum Gene Ther. 2007 Jan;18(1):81–87. doi: 10.1089/hum.2006.128

FIG. 2.

FIG. 2

Efficiency of vector genome heterodimerization with homologous- and hybrid-ITR AAV1 viruses in muscle. (A) Schematic representation of the homologous- and hybrid-ITR lacZ trans-splicing vector viral genomes used in this study. (B and C) Comparison of dual-vector heterodimerization in C57BL/6 mouse anterior tibialis muscle after infection with homologous- and hybrid-ITR vector genomes pseudotyped in AAV1 capsid. Infections were performed in the absence (B) and in the presence (C) of proteasome inhibitor Doxil. Enzymatic quantification of β-galactosidase activity in tissue lysates was performed 2 weeks postinfection. Data represent mean (+SEM) β-galactosidase activity of six independent infections for each group.