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. Author manuscript; available in PMC: 2007 Dec 7.
Published in final edited form as: Hum Gene Ther. 2007 Jan;18(1):81–87. doi: 10.1089/hum.2006.128

FIG. 4.

FIG. 4

Hybrid-ITR vector genomes enhance directional heterodimerization after infection of C57BL/6 Rag1-KO mouse liver. Directional genome heterodimerization was assessed in the liver after tail vein injection of the indicated viral combinations in the presence of Doxil. (A) β-Galactosidase enzymatic assays performed on tissue lysates 2 weeks postinfection. Data represent mean (±SEM) β-galactosidase activity of two to five independent infections for each group as indicated. (B) Morphometric quantification of X-Gal-stained mouse liver from the indicated infections (left) and representative photomicrographs of the X-Gal-stained liver sections (right). Data represent mean (±SEM) percent X-Gal-positive area observed in liver sections (n = 5 mice for each experimental group).