Table 1.
SD6 epitope MARMs isolated from FMDV C-S8c1 and FMDV C-S8c1p100
| Mutation* | Amino acid substitution† | No. of mutants
|
|
|---|---|---|---|
| C-S8c1 | C-S8c1p100 | ||
| G(412) → C | Ala-138 → Pro | 1 | 0 |
| C(413) → A | Ala-138 → Asp | 3 | 1 |
| A(415) → C | Ser-139 → Arg | 2 | 0 |
| A(415) → G | Ser-139 → Gly | 2 | 0 |
| G(416) → A | Ser-139 → Asn | 8 | 2 |
| G(416) → T | Ser-139 → Ile | 17 | 8 |
| T(417) → A | Ser-139 → Arg | 2 | 0 |
| T(417) → G | Ser-139 → Arg | 16 | 0 |
| G(425) → A | Gly-142 → Glu | 0 | 4 |
| A(428) → G | Asp-143 → Gly | 0 | 1 |
| T(430) → G | Leu-144 → Val | 0 | 5 |
| T(431) → C | Leu-144 → Ser | 0 | 8 |
| C(434) → T | Ala-145 → Val | 0 | 2 |
| A(437) → G | His-146 → Arg | 31 | 0 |
| A(437) → G | His-146 → Arg | ||
| C(446) → T | Thr-149 → Met | 1 | 0 |
*
The first letter corresponds to the wild-type nucleotide; the number gives nucleotide position in the VP1-coding region; the last letter corresponds to the mutant nucleotide.
†
The first amino acid is the one found in the wild-type virus; the number gives the amino acid position in VP1; the second amino acid is the one found in the different MARMs. The vertical line indicates the isolation of a double mutant.