Table 1.
Pcsk4 genotypes of the F2 progeny from F1 heterozygote intercrosses
| Genotype | No. of F2 mice per genotype
|
|||
|---|---|---|---|---|
| Line 417 (n = 260)
|
Line 420 (n = 372)
|
|||
| Observed | Expected | Observed | Expected | |
| +/+ | 130 (50.0) | 65 (25) | 143 (39.2) | 93 (25) |
| −/+ | 92 (35.4) | 130 (50) | 151 (40.6) | 186 (50) |
| −/− | 38 (14.6) | 65 (25) | 78 (21.0) | 93 (25) |
Lines 417 and 420 were derived from independent targeted ES clones. The number of genotyped mice in each line is indicated. The percent of each genotype is given in parentheses. The χ2 test was used to test significance. The frequency of the three genotypes in each line significantly deviates from that expected from Mendelian allele inheritance. P < 0.0001.