Table 2.
Reduced fertility of Pcsk4−/− mice
| Parents
|
n | Average litter size | % of productive matings |
|---|---|---|---|
| F M | |||
| −/+ × −/+ | 29 | 6.9 ± 1.8 | 100 |
| −/− × −/+ | 13 | 2.4 ± 2.2 (P < 0.005) | 77 (P < 0.03) |
| −/+ × −/− | 24 | 0.8 ± 1.7 (P < 0.0001) | 25 (P < 0.0001) |
Eight- to 12-week-old mice were mated for 4–6 weeks and the number of live births in the first litter was recorded. F, female; M, male; n, number of mating pairs. Values for average litter size represent means ± SD for all the mating pairs (n) in each genotype combination. Significance values (P) were calculated by Student’s t test for average litter sizes and by χ2 test for fractions of productive matings, using the −/+ matings as controls.