Figure 3.

PAC clones within the contig were hybridized to metaphase cells from patients with a del(5q). (a) PAC P299F9 hybridized to both the normal (arrow) and deleted (arrowhead) homologs in leukemia cells with a del(5)(q31q35) (patient 4 in Fig. 2). Thus, it is proximal to the commonly deleted segment. (b) Clone P318O14 is deleted on the rearranged homolog (arrowhead) in leukemia cells with a del(5)(q15q31) (patient 1 in Fig. 2). (c) Clone P98O22 is retained on the deleted (arrowhead) and normal (arrow) homologs in leukemia cells with a del(5)(q15q31) (patient 3 in Fig. 2), and is distal to the commonly deleted segment.