Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model representing putative signaling cascade modulated by chemopreventive agents for induction of phase II enzymes. ROS modulation brought about by chemopreventive agents activate signaling kinases which modify NRF2. Modified NRF2 dissociates from its inhibitor keap1 and translocates to nucleus where it heterodimerizes with other transcription factors and binds to ARE, transactivating down stream genes.
