Figure 5.

I_heat exhibits properties consistent with heat transduction in vivo. (A) Magnitude of I_heat adapts to maintained stimuli. In a neuron heated to approximately 43°C for about 2 min, I_heat reached a peak during the first minute and then decayed to a plateau level of about 50% of peak for the remainder of the stimulus. (B) PGE₂ enhances I_heat. PGE₂ (10 nM) was perfused through the recording chamber for 10 min. Within 1 min after the beginning of wash-out of PGE₂, the 43°C stimulus was reapplied. In this neuron, the peak amplitude of I_heat after exposure to PGE₂ was 192% of the control value obtained before PGE₂.