Table II. Spatial distribution of HSCs within the E12 UGR.
Tissue | No. of mice repopulated/total transplanteda |
---|---|
Gonads | 1/10 |
Mesonephroi | 4/11 |
Metanephroi | 1/2b |
UGRc | 3/7 |
Aortad | 9/11 |
AGMc | 5/6 |
aTransplanted mice received 1–2 e.e. of subdissected tissue. Only mice with ≥10% donor repopulation in the peripheral blood at 4–5 months after transfer were included as positive. Data are from a total of two independent experiments.
bFive embryo equivalents transplanted per mouse.
cNeither UGR nor AGM include metanephroi.
dAorta region: includes surrounding mesenchyme.