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Model for the requirement of a topoisomerase activity on a chromatin template in pol II transcription. We model that nucleosomes stabilize the superhelical tension, which arises during transcription elongation. The level of positive superhelical torsion is diagramed to increase with longer RNA transcripts. The relaxation activity of the topoisomerase enzyme is modeled to be required during transcription on chromatin templates, to relax the positively oriented supercoils.
