Table 1.
Comparison of agonist-induced changes in atrial myocytes and AdGIRK1+2-infected hippocampal neurons
| Agonist | ΔI−40 mV, pA/pF | ΔEM, mV | ΔgCell, nS |
|---|---|---|---|
| Myocytes | |||
| ACh | 1.8 ± 0.2 (18) | −18.9 ± 3.8 (14) | 1.2 ± 0.5 (9) |
| Neurons | |||
| Baclofen | 2.0 ± 0.3 (12) | −11.0 ± 1.0 (30) | 2.8 ± 0.4 (30) |
| 5-HT | 4.9 ± 1.1 (11) | −14.4 ± 1.9 (20) | 4.1 ± 0.5 (19) |
| 8-OH-DPAT | 1.4 ± 0.1 (2) | −10.9 ± 2.8 (8) | 4.8 ± 1.9 (7) |
| CCPA | ND | −11.0 ± 2.3 (7) | 3.9 ±1.2 (7) |
Means ± SEM (n) of changes caused by 5 μM ACh at 5.4 mM [K+]o in myocytes, and by 50 μM baclofen, 30 μM 5-HT or 8-OH-DPAT, and 3 μM CCPA at 2.5 mM [K+]o in neurons (cultured for 9–27 d, assayed 3–7 d postinfection). ND, not determined.