Table 3.
Agonist-induced excitability changes of infected hippocampal neurons
| Infection | 50 μM baclofen-induced changes
|
30 μM 5-HT-induced changes
|
||||
|---|---|---|---|---|---|---|
| ΔEM, mV | ΔgCell, nS | ΔITh, pA | ΔEM, mV | ΔgCell, nS | ΔITh, pA | |
| AdGIRK1+2 | −11.0 ± 1.0 (30) | 2.8 ± 0.4 (30) | 68 ± 18 (25) | −14.4 ± 1.9 (20) | 4.1 ± 0.5 (19) | 60 ± 14 (13) |
| AdLacZ | −3.5 ± 0.7* (18) | 0.3 ± 0.1* (18) | −3 ± 6* (11) | −1.6 ± 2.3* (7) | 0.2 ± 0.2* (7) | −14 ± 11* (5) |
| Uninfected | −3.0 ± 0.6* (21) | 0.5 ± 0.2* (18) | 4 ± 16* (12) | −0.1 ± 1.2* (5) | 0.0 ± 0.2* (5) | −20 ± 29* (3) |
Means ± SEM (n) of cells cultured for 9–27 d and assayed 3–7 d postinfection. ∗, Significant differences (P < 0.05, t test) between this value and the corresponding value from AdGIRK1+2-coinfected cells.